SYS-CON MEDIA Authors: Xenia von Wedel, Peter Silva, Glenn Rossman, Ava Smith, Elizabeth White

News Feed Item

BPA Linked to Obesity Risk in Puberty-Age Girls

OAKLAND, Calif., June 12, 2013 /PRNewswire/ -- Girls between 9 and 12 years of age with higher-than-average levels of bisphenol-A in their urine had double the risk of being obese than girls with lower levels of BPA, according to a Kaiser Permanente study published today in the journal PLOS ONE.

"This study provides evidence from a human population that confirms the findings from animal studies -- that high BPA exposure levels could increase the risk of overweight or obesity," said De-Kun Li, MD, PhD, MPH, principal investigator of the study and a reproductive and perinatal epidemiologist at the Kaiser Permanente Division of Research in Oakland, Calif.

BPA is used to make plastics and other materials, such as cash register receipts. It is a known endocrine disruptor with estrogenic properties. In children and adolescents, BPA is likely to enter the body primarily through the ingestion of foods and liquids that have come into contact with BPA-containing materials, Dr. Li said.

"Girls in the midst of puberty may be more sensitive to the impacts of BPA on their energy balance and fat metabolism," Dr. Li said. While BPA is still being examined, it has been shown to interfere with a body's process of relating fat content and distribution, he added.

The study -- among the first specifically designed to examine the relationship between BPA and obesity in school-age children -- was conducted in Shanghai as part of a larger national study of puberty and adolescent health.

Dr. Li and colleagues studied 1,326 male and female children in grades 4 to 12 at three Shanghai schools (one elementary, one middle and one high school). In addition to urine samples collected with BPA-free materials, they obtained information on other risk factors for childhood obesity, such as dietary patterns, physical activity, mental health and family history.

The researchers found that in girls between 9 and 12 years old, a higher-than-average level of BPA in urine (2 micrograms per liter or greater) was associated with twice the risk of having a body weight in the top 10th percentile for girls of their age in the same population.

The impact was particularly pronounced among 9- to 12-year-old girls with extremely high levels of BPA in their urine (more than 10 micrograms per liter): their risk of being overweight (in the top 10th percentile) was five times greater.

The researchers did not identify significant BPA effects in any other groups studied, including girls over 12 years of age and boys of all ages.

Among all the 9- to 12-year-old girls studied, 36 percent of those with a higher-than-average level of BPA in their urine were overweight or obese, compared with 21 percent of those with a lower-than-average level of BPA.

"Our study suggests that BPA could be a potential new environmental obesogen, a chemical compound that can disrupt the normal development and balance of lipid metabolism, which can lead to obesity," Dr. Li and co-authors wrote in PLOS ONE. "Worldwide exposure to BPA in the human population may be contributing to the worldwide obesity epidemic."

The PLOS ONE study is the latest in a series of studies published by Dr. Li and his colleagues examining the effects of BPA in humans:

  • Fertility and Sterility (2013): showed that male workers exposed to BPA in a chemical plant for six months or more had lower testosterone levels in their blood than with those who were not exposed to BPA in workplace.
  • Journal of Reproductive Toxicology (2011): showed that parental exposure to BPA during pregnancy was associated with decreased birth weight in offspring.
  • Birth Defects Research (Part A -- 2011): found that in-utero exposure to BPA was related to anogenital distance (the physical distance between the anus and the genitalia) in male offspring.
  • Journal of Andrology (2010): found that increasing BPA levels in urine were associated with worsening male sexual function.
  • Fertility and Sterility (2010): showed that increasing urine BPA levels were significantly associated with decreased sperm concentration, decreased total sperm count, decreased sperm vitality and decreased sperm motility.
  • Human Reproduction (2009): found that exposure to high levels of BPA in the workplace increased the risk of sexual dysfunction in men.

Kaiser Permanente is committed to researching and sourcing safer alternatives to products that may contain potentially harmful chemicals such as BPA. To that end, Kaiser Permanente's Sustainability Scorecard for Medical Products requires suppliers and manufacturers to disclose the presence of BPA in products. Most recently, the organization was able to eliminate BPA from packaging of supplemental nutrition and infant formula products.

In addition to Dr. Li, co-authors of the study were: Maohua Miao, MD, PhD, Xiaoqin Liu, MD, and Siqui Wang, PhD, Department of Epidemiology and Social Science on Reproductive Health, Shanghai Institute of Planned Parenthood Research and WHO Collaborating Center for Occupational Health, Shanghai; ZhiJun Zhou, MD, PhD, and Chunhua Wu, PhD, School of Public Health, Key Lab for Public Health and Safety and WHO Collaborating Center for Occupational Health, Fudan University, Shanghai; Huijing Shi, PhD, Department of Child and Adolescent Health, Fudan University, Shanghai; and Wei Yuan, MD, PhD, National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices, Shanghai.

The study was funded in part by National Natural Science Foundation of China (#81172684).

About the Kaiser Permanente Division of Research
The Kaiser Permanente Division of Research conducts, publishes and disseminates epidemiologic and health services research to improve the health and medical care of Kaiser Permanente members and society at large. It seeks to understand the determinants of illness and well-being, and to improve the quality and cost-effectiveness of health care. Currently, DOR's 550-plus staff is working on more than 250 epidemiological and health services research projects. For more information, visit www.dor.kaiser.org.

About Kaiser Permanente
Kaiser Permanente is committed to helping shape the future of health care. We are recognized as one of America's leading health care providers and not-for-profit health plans. Founded in 1945, our mission is to provide high-quality, affordable health care services and to improve the health of our members and the communities we serve. We currently serve more than 9.1 million members in nine states and the District of Columbia. Care for members and patients is focused on their total health and guided by their personal physicians, specialists and team of caregivers. Our expert and caring medical teams are empowered and supported by industry-leading technology advances and tools for health promotion, disease prevention, state-of-the-art care delivery and world-class chronic disease management. Kaiser Permanente is dedicated to care innovations, clinical research, health education and the support of community health. For more information, go to: kp.org/newscenter.

For more information, contact:
Catherine Hylas Saunders, [email protected], 202-585-2603
Janet Byron, [email protected], 510-891-3115

SOURCE Kaiser Permanente

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
The 4th International DevOps Summit, co-located with16th International Cloud Expo – being held June 9-11, 2015, at the Javits Center in New York City, NY – announces that its Call for Papers is now open. Born out of proven success in agile development, cloud computing, and process automation, DevOps is a macro trend you cannot afford to miss. From showcase success stories from early adopters and web-scale businesses, DevOps is expanding to organizations of all sizes, including the world's large...
"There is a natural synchronization between the business models, the IoT is there to support ,” explained Brendan O'Brien, Co-founder and Chief Architect of Aria Systems, in this SYS-CON.tv interview at the 15th International Cloud Expo®, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
Verizon Enterprise Solutions is simplifying the cloud-purchasing experience for its clients, with the launch of Verizon Cloud Marketplace, a key foundational component of the company's robust ecosystem of enterprise-class technologies. The online storefront will initially feature pre-built cloud-based services from AppDynamics, Hitachi Data Systems, Juniper Networks, PfSense and Tervela. Available globally to enterprises using Verizon Cloud, Verizon Cloud Marketplace provides a one-stop shop fo...
Leysin American School is an exclusive, private boarding school located in Leysin, Switzerland. Leysin selected an OpenStack-powered, private cloud as a service to manage multiple applications and provide development environments for students across the institution. Seeking to meet rigid data sovereignty and data integrity requirements while offering flexible, on-demand cloud resources to users, Leysin identified OpenStack as the clear choice to round out the school's cloud strategy. Additional...
The major cloud platforms defy a simple, side-by-side analysis. Each of the major IaaS public-cloud platforms offers their own unique strengths and functionality. Options for on-site private cloud are diverse as well, and must be designed and deployed while taking existing legacy architecture and infrastructure into account. Then the reality is that most enterprises are embarking on a hybrid cloud strategy and programs. In this Power Panel at 15th Cloud Expo (http://www.CloudComputingExpo.com...
We are all here because we are sold on the transformative promise of The Cloud. But what good is all of this ephemeral, on-demand infrastructure if your usage doesn't actually improve the agility and speed of your business? How must Operations adapt in order to avoid stifling your Cloud initiative? In his session at DevOps Summit, Damon Edwards, co-founder and managing partner of the DTO Solutions, will highlight the successful organizational, process, and tooling patterns of high-performing c...
The definition of IoT is not new, in fact it’s been around for over a decade. What has changed is the public's awareness that the technology we use on a daily basis has caught up on the vision of an always on, always connected world. If you look into the details of what comprises the IoT, you’ll see that it includes everything from cloud computing, Big Data analytics, “Things,” Web communication, applications, network, storage, etc. It is essentially including everything connected online from ha...
Software-driven innovation is becoming a primary approach to how businesses create and deliver new value to customers. A survey of 400 business and IT executives by the IBM Institute for Business Value showed businesses that are more effective at software delivery are also more profitable than their peers nearly 70 percent of the time (1). DevOps provides a way for businesses to remain competitive, applying lean and agile principles to software development to speed the delivery of software that ...
Docker offers a new, lightweight approach to application portability. Applications are shipped using a common container format and managed with a high-level API. Their processes run within isolated namespaces that abstract the operating environment independently of the distribution, versions, network setup, and other details of this environment. This "containerization" has often been nicknamed "the new virtualization." But containers are more than lightweight virtual machines. Beyond their small...
The move in recent years to cloud computing services and architectures has added significant pace to the application development and deployment environment. When enterprise IT can spin up large computing instances in just minutes, developers can also design and deploy in small time frames that were unimaginable a few years ago. The consequent move toward lean, agile, and fast development leads to the need for the development and operations sides to work very closely together. Thus, DevOps become...
Cloud Expo 2014 TV commercials will feature @ThingsExpo, which was launched in June, 2014 at New York City's Javits Center as the largest 'Internet of Things' event in the world.

ARMONK, N.Y., Nov. 20, 2014 /PRNewswire/ --  IBM (NYSE: IBM) today announced that it is bringing a greater level of control, security and flexibility to cloud-based application development and delivery with a single-tenant version of Bluemix, IBM's

An entirely new security model is needed for the Internet of Things, or is it? Can we save some old and tested controls for this new and different environment? In his session at @ThingsExpo, New York's at the Javits Center, Davi Ottenheimer, EMC Senior Director of Trust, reviewed hands-on lessons with IoT devices and reveal a new risk balance you might not expect. Davi Ottenheimer, EMC Senior Director of Trust, has more than nineteen years' experience managing global security operations and asse...
Explosive growth in connected devices. Enormous amounts of data for collection and analysis. Critical use of data for split-second decision making and actionable information. All three are factors in making the Internet of Things a reality. Yet, any one factor would have an IT organization pondering its infrastructure strategy. How should your organization enhance its IT framework to enable an Internet of Things implementation? In his session at Internet of @ThingsExpo, James Kirkland, Chief Ar...
Technology is enabling a new approach to collecting and using data. This approach, commonly referred to as the "Internet of Things" (IoT), enables businesses to use real-time data from all sorts of things including machines, devices and sensors to make better decisions, improve customer service, and lower the risk in the creation of new revenue opportunities. In his General Session at Internet of @ThingsExpo, Dave Wagstaff, Vice President and Chief Architect at BSQUARE Corporation, discuss the ...