SYS-CON MEDIA Authors: Trevor Parsons, Sean Houghton, Glenn Rossman, Ignacio M. Llorente, Xenia von Wedel

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Global Drug Delivery in Central Nervous System Diseases Report

DUBLIN, Ireland, January 28, 2014 /PRNewswire/ --

Research and Markets (http://www.researchandmarkets.com/research/f4fdv2/drug_delivery_in) has announced the addition of a new report "Global Drug Delivery in Central Nervous System Diseases Report" to their offering. 
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The delivery of drugs to central nervous system (CNS) is a challenge in the treatment of neurological disorders. Drugs may be administered directly into the CNS or administered systematically (e.g., by intravenous injection) for targeted action in the CNS. The major challenge to CNS drug delivery is the blood-brain barrier (BBB), which limits the access of drugs to the brain substance.

Advances in understanding of the cell biology of the BBB have opened new avenues and possibilities for improved drug delivery to the CNS. Several carrier or transport systems, enzymes, and receptors that control the penetration of molecules have been identified in the BBB endothelium. Receptor-mediated transcytosis can transport peptides and proteins across the BBB. Methods are available to assess the BBB permeability of drugs at the discovery stage to avoid development of drugs that fail to reach their target site of action in the CNS.

Various strategies that have been used for manipulating the blood-brain barrier for drug delivery to the brain include osmotic and chemical opening of the blood-brain barrier as well as the use of transport/carrier systems. Other strategies for drug delivery to the brain involve bypassing the BBB. Various pharmacological agents have been used to open the BBB and direct invasive methods can introduce therapeutic agents into the brain substance. It is important to consider not only the net delivery of the agent to the CNS, but also the ability of the agent to access the relevant target site within the CNS. Various routes of administration as well as conjugations of drugs, e.g., with liposomes and nanoparticles, are considered. Some routes of direct administration to the brain are non-invasive such as transnasal route whereas others involve entry into the CNS by devices and needles such as in case of intrathecal and intracerebroventricular delivery. Systemic therapy by oral and parenteral routes is considered along with sustained and controlled release to optimize the CNS action of drugs. Among the three main approaches to drug delivery to the CNS - systemic administration, injection into CSF pathways, and direct injection into the brain - the greatest developments is anticipated to occur in the area of targeted delivery by systemic administration.

Many of the new developments in the treatment of neurological disorders will be biological therapies and these will require innovative methods for delivery. Cell, gene and antisense therapies are not only innovative treatments for CNS disorders but also involve sophisticated delivery methods. RNA interference (RNAi) as a form of antisense therapy is also described.


Key Topics Covered: 

Executive Summary 

1. Basics of Drug Delivery to the Central Nervous System 

2. Blood Brain Barrier 

3. Methods of Drug Delivery to the CNS 

4. Delivery of Cell, Gene and Antisense Therapies to the CNS 

5. Drug Delivery for Treatment of Neurological Disorders 

6. Drug delivery for brain tumors 

7. Markets for Drug Delivery in CNS Disorders 

8. Companies 

9. References 


For more information visit http://www.researchandmarkets.com/research/f4fdv2/drug_delivery_in


Media Contact: Laura Wood , +353-1-481-1716, [email protected]


SOURCE Research and Markets

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