SYS-CON MEDIA Authors: Liz McMillan, Plutora Blog, Trevor Parsons, Elizabeth White, Pat Romanski

News Feed Item

Creabilis to Present CT327 Phase 2b Data at American Academy of Dermatology (AAD) Annual Meeting

CANTERBURY, England, March 21, 2014 /PRNewswire/ --


  • Phase  2b  data  demonstrates  a  60%  reduction  in  pruritus  in  psoriatic  patients  treated  with  CT327
  • Data  analysis  also  published  in  the  Journal  of  the  American  Academy  of  Dermatology
  • Phase  2b  CT327  topline  data  in  patients  with  Atopic  Dermatitis  and  Pruritus  due  in  mid-2014

 

Creabilis Ltd, the dermatology company with the most advanced targeted topical treatment in development for chronic pruritus (itch), announces that data from its Phase 2b trial of lead compound, CT327, will be presented in The Latest in Dermatology Research Symposia at the 72nd Annual Meeting of the AAD in Denver, Colorado, USA. Professor Gil Yosipovitch, Chair of the Department of Dermatology at the Temple University School of Medicine and Director of the Temple Center for Itch, will present the data on Saturday  22  March  at  16.15pm  CST.

CT327 is a novel topical targeted treatment for chronic pruritus in diseases of dermatology, such as psoriasis and atopic dermatitis, targeting the sensory neurones implicated in the disease through the inhibition of TrkA kinase.  Chronic pruritus is an area of significant unmet need with no approved therapies. Existing anti-inflammatory therapies that have also been tried in the treatment of pruritus are often ineffective and poorly tolerated.

The presentation (Abstract #1470), "A  novel  topical  targeted  anti-pruritic  treatment  in  Phase  2b  development  for  chronic  pruritus" will focus on the debilitating nature of chronic pruritus and importance of a targeted anti-pruritic approach for its treatment. Professor Yosipovitch will also present the recent Phase 2b data using CT327 in the treatment of pruritus in 160 psoriatic patients.  In this clinical trial, patients receiving CT327 showed a statistically significant and clinically meaningful reduction in pruritus compared to blinded vehicle emollient. Pruritus was measured using a visual analogue scale (VAS), the accepted regulatory endpoint for pruritus. The reduction from baseline in pruritus VAS reached 60% for patients treated with CT327 compared to 20% for patient treated with vehicle (p<0.05). Up to 62% of patients treated with CT327 achieved at least a 50% reduction in pruritus VAS compared to 32% of patients on vehicle (p<0.05). At baseline, 69% of patients reported at least moderate pruritus (VAS > 40mm). CT327 was safe and well tolerated, with no application site reactions.  

The abstract can be accessed at http://www.aad.org/File%20Library/Unassigned/AM14-Latest-in-Derm-Abstract-Book-FINAL-Version-2.pdf

Publication  in  the  Journal  of  the  American  Academy  of  Dermatology

Creabilis also announces that it has published new results demonstrating that pruritus severity in psoriasis patients is not correlated with psoriasis disease severity in a letter to the Journal of the American Academy of Dermatology (JAAD).  

An analysis of data drawn from Creabilis' Phase 2b study of CT327 in psoriasis patients showed no correlation between baseline pruritus severity and psoriasis disease severity.

The letter can be found online at: http://www.jaad.org/article/S0190-9622(13)01012-8/fulltext

Dr  Eliot  Forster,  Chief  Executive  Officer  of  Creabilis,  commented: "Chronic pruritus is a major clinical problem with significant market potential, where no topical medicines are currently approved.  With the powerful efficacy and differentiated safety profile seen in this clinical trial, CT327 has the potential to be the first targeted topical anti-pruritic to come to market for this common condition.

"Presenting these data at such a prestigious conference and in a leading dermatology journal demonstrates the clinical significance of these data to the dermatology community. . We very much look forward to receiving the Phase 2b data in patients with pruritus in Atopic Dermatitis later this year."

Professor  Gil  Yosipovitch,  Creabilis  Scientific  Advisory  Board  Member,  said: "Chronic Pruritus has a significant impact on the quality of life of patients with Psoriasis. These data give me hope that my patients will soon have a potent topical treatment option using this targeted anti-pruritic."

Notes  to  Editors:

About  Pruritus

Chronic pruritus (itch) is a debilitating symptom of many dermatological diseases and has a significant impact on quality of life. Patients with chronic pruritus often have multiple episodes per day, scratch until bleeding, and are unable to sleep, resulting in broader socioeconomic and psychosocial problems for these patients, including impacts on school, work attendance, and depression. Pruritus is the cardinal symptom in Atopic Dermatitis and one of the most important symptoms of Psoriasis. There is no medicine currently approved for the topical treatment of chronic pruritus. A recent study found no existing treatment relieved pruritus in 45% of psoriatics.

About  Pruritus  and  CT327

CT327 inhibits the intracellular kinase of the TrkA receptor, the high affinity receptor for Nerve Growth Factor (NGF), and consequently reduces the peripheral sensitisation of sensory neurons, a process that plays a pivotal role in the pathogenesis of pruritus.

About  Creabilis 

Creabilis is a dermatology company with the most advanced targeted topical treatment in development for chronic pruritus (itch). Creabilis has delivered positive Phase 2b results for CT327 in the treatment of pruritus in psoriasis patients. CT327 was developed using Creabilis' proprietary Low Systemic Exposure (LSE) 'topical-by-design' technology that creates molecules optimized for topical applications. Planning for Phase 3 with CT327 is underway, with a clear route to market. Creabilis' pipeline also includes CT340, an IND-ready and potent narrow spectrum kinase inhibitor in development for the topical treatment of chronic pain.

Creabilis is backed by highly respected life science investors Sofinnova Partners, Neomed and AbbVie Biotech Ventures Inc., and is led by an experienced Management team. Creabilis' Corporate Headquarters and Development functions are based in the UK, with Research activities in Italy.

More information can be found at: http://www.creabilis-sa.com

Further  information:

Creabilis
Eliot Forster
Chief Executive Officer
Email: [email protected]

Consilium  Strategic  Communications
Amber Bielecka, Jessica Hodgson, Melissa Jumbo
Tel: +44(0)203-709-5700
Email: [email protected]


SOURCE Creabilis

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
Docker offers a new, lightweight approach to application portability. Applications are shipped using a common container format and managed with a high-level API. Their processes run within isolated namespaces that abstract the operating environment independently of the distribution, versions, network setup, and other details of this environment. This "containerization" has often been nicknamed "the new virtualization." But containers are more than lightweight virtual machines. Beyond their small...
The industrial software market has treated data with the mentality of “collect everything now, worry about how to use it later.” We now find ourselves buried in data, with the pervasive connectivity of the (Industrial) Internet of Things only piling on more numbers. There’s too much data and not enough information. In his session at @ThingsExpo, Bob Gates, Global Marketing Director, GE’s Intelligent Platforms business, to discuss how realizing the power of IoT, software developers are now focu...
The Internet of Things is tied together with a thin strand that is known as time. Coincidentally, at the core of nearly all data analytics is a timestamp. When working with time series data there are a few core principles that everyone should consider, especially across datasets where time is the common boundary. In his session at Internet of @ThingsExpo, Jim Scott, Director of Enterprise Strategy & Architecture at MapR Technologies, discussed single-value, geo-spatial, and log time series dat...
15th Cloud Expo, which took place Nov. 4-6, 2014, at the Santa Clara Convention Center in Santa Clara, CA, expanded the conference content of @ThingsExpo, Big Data Expo, and DevOps Summit to include two developer events. IBM held a Bluemix Developer Playground on November 5 and ElasticBox held a Hackathon on November 6. Both events took place on the expo floor. The Bluemix Developer Playground, for developers of all levels, highlighted the ease of use of Bluemix, its services and functionalit...
Today’s enterprise is being driven by disruptive competitive and human capital requirements to provide enterprise application access through not only desktops, but also mobile devices. To retrofit existing programs across all these devices using traditional programming methods is very costly and time consuming – often prohibitively so. In his session at @ThingsExpo, Jesse Shiah, CEO, President, and Co-Founder of AgilePoint Inc., discussed how you can create applications that run on all mobile ...
In her General Session at 15th Cloud Expo, Anne Plese, Senior Consultant, Cloud Product Marketing, at Verizon Enterprise, focused on finding the right mix of renting vs. buying Oracle capacity to scale to meet business demands, and offer validated Oracle database TCO models for Oracle development and testing environments. Anne Plese is a marketing and technology enthusiast/realist with over 19+ years in high tech. At Verizon Enterprise, she focuses on driving growth for the Verizon Cloud platfo...
At 15th Cloud Expo, Shrikant Pattathil, Executive Vice President at Harbinger Systems, demos a video delivery platform that helps you do interactive videos. He discusses how Harbinger is accomplishing it in the cloud world, the problems they faced and the choices they made to get around these problems.
Between the compelling mockups and specs produced by your analysts and designers, and the resulting application built by your developers, there is a gulf where projects fail, costs spiral out of control, and applications fall short of requirements. In his session at DevOps Summit, Charles Kendrick, CTO and Chief Architect at Isomorphic Software, will present a new approach where business and development users collaborate – each using tools appropriate to their goals and expertise – to build mo...
There is no doubt that Big Data is here and getting bigger every day. Building a Big Data infrastructure today is no easy task. There are an enormous number of choices for database engines and technologies. To make things even more challenging, requirements are getting more sophisticated, and the standard paradigm of supporting historical analytics queries is often just one facet of what is needed. As Big Data growth continues, organizations are demanding real-time access to data, allowing immed...
The 3rd International Internet of @ThingsExpo, co-located with the 16th International Cloud Expo - to be held June 9-11, 2015, at the Javits Center in New York City, NY - announces that its Call for Papers is now open. The Internet of Things (IoT) is the biggest idea since the creation of the Worldwide Web more than 20 years ago.
Scott Jenson leads a project called The Physical Web within the Chrome team at Google. Project members are working to take the scalability and openness of the web and use it to talk to the exponentially exploding range of smart devices. Nearly every company today working on the IoT comes up with the same basic solution: use my server and you'll be fine. But if we really believe there will be trillions of these devices, that just can't scale. We need a system that is open a scalable and by using ...
In their session at @ThingsExpo, Shyam Varan Nath, Principal Architect at GE, and Ibrahim Gokcen, who leads GE's advanced IoT analytics, focused on the Internet of Things / Industrial Internet and how to make it operational for business end-users. Learn about the challenges posed by machine and sensor data and how to marry it with enterprise data. They also discussed the tips and tricks to provide the Industrial Internet as an end-user consumable service using Big Data Analytics and Industrial C...
Things are being built upon cloud foundations to transform organizations. This CEO Power Panel at 15th Cloud Expo, moderated by Roger Strukhoff, Cloud Expo and @ThingsExpo conference chair, addressed the big issues involving these technologies and, more important, the results they will achieve. Rodney Rogers, chairman and CEO of Virtustream; Brendan O'Brien, co-founder of Aria Systems, Bart Copeland, president and CEO of ActiveState Software; Jim Cowie, chief scientist at Dyn; Dave Wagstaff, VP ...
How do APIs and IoT relate? The answer is not as simple as merely adding an API on top of a dumb device, but rather about understanding the architectural patterns for implementing an IoT fabric. There are typically two or three trends: Exposing the device to a management framework Exposing that management framework to a business centric logic Exposing that business layer and data to end users. This last trend is the IoT stack, which involves a new shift in the separation of what stuff happe...
"For the past 4 years we have been working mainly to export. For the last 3 or 4 years the main market was Russia. In the past year we have been working to expand our footprint in Europe and the United States," explained Andris Gailitis, CEO of DEAC, in this SYS-CON.tv interview at Cloud Expo, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.