|By Marketwired .||
|April 2, 2014 11:23 AM EDT||
NEW YORK, NY -- (Marketwired) -- 04/02/14 -- Patients underdoing adjuvant radiation therapy for localized prostate cancer may benefit from a significantly reduced course of androgen deprivation therapy (ADT). In comparing the outcomes of 18-month and 36-month ADT courses, Canadian researchers found comparable disease-free survival rates and reduced side effects. The findings suggest that halving the traditional 36-month dosing could reduce costs and improve patients' quality of life without jeopardizing treatment benefits.
To more aggressively target cancer cells, androgen blockade therapy is commonly added to standard pelvic radiotherapy in patients with high-risk, node-negative prostate cancer. Based on a study of 630 men, researchers report that halving the ADT course to 18 months safely and comparably addresses node and bone metastases. New York robotic prostate surgeon, David B. Samadi, MD, is encouraged by these findings.
"Long-term use of androgen blockades can lead to low testosterone and impotence," said Dr. Samadi, Chairman of Urology and Chief of Robotic Surgery at Lenox Hill Hospital. "Prostate cancer treatment side effects and their duration are of top concern when patients evaluate prostate cancer treatments such as robotic prostatectomy, radiation therapy and hormone therapy."
The study was conducted across 10 Canadian centers from October 2000 through January 2008. Radiation patients were randomly assigned to 18 months and 36 months of simultaneous androgen blockade therapy. In a multivariate analysis, all participants had similar PSA levels, Gleason scores and disease stages. At five- and 10-year follow-ups, the differences in mortality and biochemical failure rates between the 18-month and 36-month groups were not statistically significant. Pelvic node metastases and bone metastases were also comparable.
Researchers are hopeful that the 18-month mark may represent a threshold beyond which no additional ADT benefit is realized. If so, patients could face a shorter duration of side effects such as erectile dysfunction (ED). Findings were presented at the 2013 Genitourinary Cancers Symposium, http://meetinglibrary.asco.org/content/107219-134
The quality of life data from the study are under continued review and likely will be published in a follow-up report later this year.
Radiation therapy and hormone therapy for prostate cancer are disease management modalities. Whereas robotic surgery removes the cancer from the body, radiation and hormone therapy treat it in place. Side effects of hormone therapy may include bone weakening and cancer treatment-induced bone loss, acute kidney injury, erectile dysfunction, fatigue and depression.
Image Available: http://www2.marketwire.com/mw/frame_mw?attachid=2558091
David B. Samadi, M.D.
Chairman of Urology
Chief of Robotic Surgery at Lenox Hill Hospital
485 Madison Avenue
New York, NY 10022
As cloud gives an opportunity to businesses to buy services externally - how is cloud impacting your customers? In his General Session at 15th Cloud Expo, Fabio Gori, Director of Worldwide Cloud Marketing at Cisco, will provide answers to big questions: Do you see hybrid cloud as where the world is going? What benefits does it bring? And how does Cisco connect all of these clouds? He will also te...
Oct. 31, 2014 06:45 PM EDT Reads: 846
Can we look to the paradigm of cloud computing from a completely different perspective? In his General Session at 15th Cloud Expo, Gundars Kulups, Sales Director at DEAC, will discuss what we can learn from our dining habits when choosing a cloud solution. Gundars Kulups is Sales Director at DEAC, full service data center operator. An IT expert, he specializes in European countries and has worke...
Oct. 31, 2014 06:45 PM EDT Reads: 720
SYS-CON Events announced today that TMCnet has been named “Media Sponsor” of SYS-CON's 15th International Cloud Expo®, which will take place on November 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. Technology Marketing Corporation (TMC) is the world's leading business to business and integrated marketing media company, servicing niche markets within the communications and t...
Oct. 31, 2014 06:30 PM EDT Reads: 846
SYS-CON Events announced today that Aria Systems, the recurring revenue expert, has been named "Bronze Sponsor" of SYS-CON's 15th International Cloud Expo®, which will take place on November 4-6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. Aria Systems helps leading businesses connect their customers with the products and services they love. Industry leaders like Pitney Bowes, E...
Oct. 31, 2014 06:30 PM EDT Reads: 2,136
The 4th International DevOps Summit, co-located with16th International Cloud Expo – being held June 9-11, 2015, at the Javits Center in New York City, NY – announces that its Call for Papers is now open. Born out of proven success in agile development, cloud computing, and process automation, DevOps is a macro trend you cannot afford to miss. From showcase success stories from early adopters and ...
Oct. 31, 2014 06:15 PM EDT Reads: 2,145
We live in a time when seconds – even milliseconds – can have a dramatic economic impact on your company’s future. With technology being the primary conduit for consumer interaction, the user experience is at center stage. User experience will be a deciding factor in separating the future winners from the losers. By building more speed and agility into the application delivery process, DevOps prom...
Oct. 31, 2014 06:00 PM EDT Reads: 1,391
SYS-CON Events announced today that AgilePoint, the leading provider of Microsoft-centric Business Process Management software, will exhibit at SYS-CON's 2nd International @ThingsExpo which will take place on November 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. AgilePoint is the leading provider of Microsoft-based Business Process Management (BPM) software products, has 1,...
Oct. 31, 2014 05:00 PM EDT Reads: 1,132
SYS-CON Events announced today that Parasoft will exhibit at SYS-CON's 15th International Cloud Expo®, which will take place on November 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. For 27 years, Parasoft has researched and developed software solutions that help organizations deliver defect-free software efficiently. By integrating Development Testing, API/cloud/SOA/composi...
Oct. 31, 2014 05:00 PM EDT Reads: 1,023
The Internet of Things (IoT) promises to evolve the way the world does business; however, understanding how to apply it to your company can be a mystery. Most people struggle with understanding the potential business uses or tend to get caught up in the technology, resulting in solutions that fail to meet even minimum business goals. In his session at Internet of @ThingsExpo, Jesse Shiah, CEO / ...
Oct. 31, 2014 04:00 PM EDT Reads: 1,577
SYS-CON Events announced today that Utimaco will exhibit at SYS-CON's 15th International Cloud Expo®, which will take place on November 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. Utimaco is a leading manufacturer of hardware based security solutions that provide the root of trust to keep cryptographic keys safe, secure critical digital infrastructures and protect high val...
Oct. 31, 2014 03:00 PM EDT Reads: 1,938