|By Business Wire
|May 14, 2014 08:09 AM EDT
Inc., a company pioneering the development of precision therapies
for genetic heart disease, today announced the launch of the Sarcomeric
Registry (SHaRe), a multi-center,
international repository of clinical data on individuals with genetic
heart disease. The registry was developed in collaboration with
investigators from seven world-leading cardiovascular centers and
currently contains de-identified data on over 5,800 subjects. SHaRe aims
to grow into the world’s most robust database of clinical information on
genetic heart disease through relationships with additional clinical
investigators and cardiovascular centers of excellence.
SHaRe is a first-of-its-kind effort that promises to yield a deeper
understanding of genetic heart disease and pave the way for more
targeted and effective approaches to treating the disease. Two types of
genetic heart disease, hypertrophic cardiomyopathy (HCM) and dilated
cardiomyopathy (DCM), together affect nearly 800,000 people in the
United States, but treatment to halt the progression of disease has
remained elusive due to the complex and varied nature of these
conditions. Mutations in the molecular motor of the heart, the
sarcomere, are an important cause of these inherited heart muscle
disorders. Patients with HCM and DCM do not all share the same
disease-causing genetic mutations, or genotype. There are many different
clinical characteristics, or phenotypes, in part driven by their
individual genetic makeup. SHaRe will play an important role in helping
researchers and clinicians better understand how these genotypes and
phenotypes interact, which will ultimately lead to the development of
targeted therapies based on the specific disease-causing genetic
mutations in individual patients.
“Genetic heart disease can present itself in both children and adults.
Moreover, the burden of symptoms and the severity of disease are highly
variable,” said Carolyn Ho, M.D., assistant professor of medicine at
Harvard Medical School, medical director of the Cardiovascular Genetics
Center at Brigham and Women’s Hospital and lead SHaRe investigator. “Our
goal in creating SHaRe is to critically advance the understanding of HCM
and DCM. By amassing these detailed longitudinal and centralized data,
we hope to generate better predictors of risk and disease progression.
With this information, we can better understand why some patients do
poorly, and as importantly, why some patients do well. By redefining and
refining phenotypes and modifiers of outcome in genetic heart disease,
we ultimately hope to improve the care of our patients and families.”
The centers of excellence currently participating in SHaRe include
Brigham and Women’s Hospital, Boston; University of Michigan Medical
Center; Stanford University Medical Center; Boston Children’s Hospital;
The Heart Hospital, University College London, U.K.; Florence Centre for
Cardiomyopathies, Italy; and Erasmus University Medical Center,
Despite the often devastating effect on families, public awareness and
understanding of genetic heart disease remains low. As part of SHaRe, a
companion website has been launched to provide patients, families
and communities with information about heritable cardiomyopathies, SHaRe
centers and investigators, related research activities and other genetic
heart disease information.
“Together with our SHaRe collaborators, MyoKardia is committed to
helping patients with genetic heart disease and their families,” said
Jonathan C. Fox, M.D., Ph.D., chief medical officer of MyoKardia and
consulting professor at the Stanford Cardiovascular Institute.
“Currently available treatment options for patients with heritable
cardiomyopathies are limited and do not target the primary cause of the
disease. For these patients, a ‘one-size-fits-all’ approach to therapy
simply won’t work. The insights gleaned from this large database of
clinical information will allow us to better tailor our programs in HCM
and DCM and advance our goal of enabling precision medicines for
patients with genetic heart disease.”
MyoKardia is developing a pipeline of novel, small-molecule targeted
therapeutics to treat genetic heart disease based on mutations in heart
muscle that are known to cause the disease. The company’s current
programs are focused on both HCM and DCM, for which no therapeutics have
ever been approved.
About Genetic Heart Disease
Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are
types of genetic heart disease that are caused by mutations in the
protein genes of the sarcomere, the fundamental contractile unit of
heart muscle, and passed on in families in an autosomal dominant pattern
of inheritance. HCM impacts an estimated one in 500 people in the
general population by producing thickening of the heart walls and is
recognized as a cause of sudden cardiac death, the most common cause of
non-traumatic death in young adults. DCM produces weakening of the heart
walls and enlargement of the heart chambers and is estimated to occur in
one in 2,500 people in the general population. The prevalence of HCM and
DCM, taken together, is estimated at nearly 800,000 people in the United
States, affecting both children and adults.
MyoKardia, Inc. is dedicated to revolutionizing the treatment of genetic
heart diseases through the development of novel, small-molecule targeted
therapeutics that address the underlying cause of disease. By combining
leading-edge cardiovascular genetics with recent advances in heart
muscle biochemistry, MyoKardia seeks to usher in an era of precision
medicine that will dramatically improve the treatment of
cardiomyopathies and make a meaningful difference in the lives of people
with genetic heart disease. Launched in 2012 by a group of researchers
widely acknowledged as the world leaders in their fields, MyoKardia is
funded by leading life sciences investor Third Rock Ventures. For more
information, please visit www.myokardia.com.
Artifactory binary repository management system. As one of the most widely used binary repositories and the only repository that offers a high availability clustered solution, the integration with Artifactory helps customers easily adopt CA Release Automation to optimize their entire software development lifecycle.
“Artifactory is a standard maker at the continuous-integration domain and provides the user a powerful repository experience with the freedom to choose his own tools set and ecosyste...
May. 5, 2015 07:45 PM EDT Reads: 476
This talk focuses on the application of DevOps fundamentals to include network infrastructure. It draws from real deployment case studies on the extension of today's paradigms to address the challenges of the network infrastructures' ability to seamlessly and cohesively integrate into agile workflows.
In this session at DevOps Summit, Arista Networks will focus on configuration management using automation with a nod to future work necessary to include telemetry and ephemeral state information....
May. 5, 2015 04:45 PM EDT Reads: 1,129
Avnet, Inc. has announced that it ranked No. 4 on the InformationWeek Elite 100 – a list of the top business technology innovators in the U.S. Avnet was recognized for the development of an innovative cloud-based training system that serves as the foundation for Avnet Academy – the company’s education and training organization focused on technical training around top IT vendor technologies. The development of this system allowed Avnet to quickly expand its IT-related training capabilities around...
May. 5, 2015 04:15 PM EDT Reads: 939
SYS-CON Events announced today that dcVAST, a leader in IT infrastructure management, support service and cloud service, will exhibit at SYS-CON's 16th International Cloud Expo®, which will take place on June 9-11, 2015, at the Javits Center in New York City, NY.
dcVAST provides cutting-edge IT services and IT infrastructure management services. dcVAST builds robust systems that are simple, secure and serviceable. dcVAST’s IT infrastructure support and IT services expertise can help companies r...
May. 5, 2015 04:02 PM EDT Reads: 611
DevOps Summit, taking place Nov 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 17th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world.
The widespread success of cloud computing is driving the DevOps revolution in enterprise IT. Now as never before, development teams must communicate and collaborate in a dynamic, 24/7/365 environment. There is no time to wait for long developmen...
May. 5, 2015 03:45 PM EDT Reads: 899
While Docker continues to be the darling of startups, enterprises and IT innovators around the world, networking continues to be a real mess. Indeed, managing the interaction between Docker containers and networks has always been fraught with complications. Without automation in networking, the vision of running Docker at scale and letting IT run the same apps unchanged on the laptop and in the data center or for any cloud cannot be realized.
May. 5, 2015 03:30 PM EDT Reads: 933
SYS-CON Events announced today Isomorphic Software, the global leader in high-end, web-based business applications, will exhibit at SYS-CON's DevOps Summit 2015 New York, which will take place on June 9-11, 2015, at the Javits Center in New York City, NY.
Isomorphic Software is the global leader in high-end, web-based business applications. We develop, market, and support the SmartClient & Smart GWT HTML5/Ajax platform, combining the productivity and performance of traditional desktop software ...
May. 5, 2015 03:00 PM EDT Reads: 840
The OnPage SOAP API provides programmatic access to OnPage messaging services.
Typical applications include sending messages to individual OnPage users or groups and receiving tracking information for messages such as delivery and read timestamps or reply information.
The API is based on open standards known collectively as "Web Services," which includes the Simple Object Access Protocol (SOAP), Web Services Definition Language (WSDL), and the XML Schema Definition language (XSD).
May. 5, 2015 02:37 PM EDT Reads: 351
SYS-CON Events announced today the DevOps Foundation Certification Course, being held June ?, 2015, in conjunction with DevOps Summit and 16th Cloud Expo at the Javits Center in New York City, NY.
This sixteen (16) hour course provides an introduction to DevOps – the cultural and professional movement that stresses communication, collaboration, integration and automation in order to improve the flow of work between software developers and IT operations professionals. Improved workflows will res...
May. 5, 2015 02:30 PM EDT Reads: 3,396
Docker is becoming very popular--we are seeing every major private and public cloud vendor racing to adopt it. It promises portability and interoperability, and is quickly becoming the currency of the Cloud.
In his session at DevOps Summit, Bart Copeland, CEO of ActiveState, discussed why Docker is so important to the future of the cloud, but will also take a step back and show that Docker is actually only one piece of the puzzle. Copeland will outline the bigger picture of where Docker fits a...
May. 5, 2015 02:15 PM EDT Reads: 5,327
Ayla Networks, whose agile Internet of Things (IoT) platform makes it easy for manufacturers to deliver secure, connected products, today announced it has been included in the list of "Cool Vendors" in the Internet of Things report by Gartner, Inc.
“Gartner knows how important it is that manufacturers of all kinds of products have the right IoT solution to help turn their products into connected ‘things,’” said David Friedman, CEO and co-founder of Ayla Networks. “The market for Ayla’s IoT pla...
May. 5, 2015 02:00 PM EDT Reads: 507
A new definition of Big Data & the practical applications of the defined components & associated technical architecture models
This presentation introduces a new definition of Big Data, along with the practical applications of the defined components and associated technical architecture models.
In his session at Big Data Expo, Tony Shan will start with looking into the concept of Big Data and tracing back the first definition by Doug Laney, and then he will dive deep into the description of 3V...
May. 5, 2015 02:00 PM EDT Reads: 1,141
SYS-CON Events announced today that CenturyLink, Inc., a leader in the network services market, has been named “Platinum Sponsor” of SYS-CON's 16th International Cloud Expo®, which will take place on June 9-11, 2015, at the Javits Center in New York City, NY.
CenturyLink is the third largest telecommunications company in the United States and is recognized as a leader in the network services market by technology industry analyst firms. The company is a global leader in cloud infrastructure and ...
May. 5, 2015 01:15 PM EDT Reads: 1,286
ScriptRock has been included in the list of "Cool Vendors" in the "Cool Vendors in DevOps 2015" report by Gartner, Inc.*
ScriptRock provides visibility into the configuration state of an organization's IT environments, enabling the continuous delivery of mission critical services. For enterprises where downtime is not an option, ScriptRock's system-wide overwatch offers the assurance that misconfigurations and anomalies are caught before they affect the business. By satisfying this fundamental ...
May. 5, 2015 12:15 PM EDT Reads: 771
As cloud gives an opportunity to businesses to buy services externally – how is cloud impacting your customers?
In his General Session at 15th Cloud Expo, Fabio Gori, Director of Worldwide Cloud Marketing at Cisco, provided answers to big questions: Do you see hybrid cloud as where the world is going? What benefits does it bring? And how does Cisco connect all of these clouds? He also discussed Intercloud and Cisco’s investment on it.
May. 5, 2015 12:00 PM EDT Reads: 5,155