|By Business Wire||
|June 16, 2014 07:06 AM EDT||
AB SCIEX, a global leader in life science analytical technologies, today introduced the TripleTOF® 6600 system with SWATH™ Acquisition 2.0 – the company’s revolutionary solution for quantitative proteomics. This high-resolution, accurate-mass system, combined with the new SWATH™ Acquisition 2.0, brings new power to proteomic data challenges for advanced biomarker discovery and systems biology. As the emphasis in proteomics research shifts from cataloguing to comprehensive quantitation, the AB SCIEX solution is uniquely positioned, enabling the quantification of thousands of proteins across large sample sets with a level of data completeness and quantitative accuracy and precision that have only been achievable by “gold-standard,” targeted MRM in the past.
“The TripleTOF 6600 system with SWATH 2.0 truly transforms proteomics research by providing an advanced level of data completeness and quantitative accuracy,” said Rainer Blair, President of AB SCIEX, “The new platform empowers researchers to gain greater insights into biomarkers and disease pathways, which will lead to earlier disease detection and, some day, personalized therapies.”
AB SCIEX SWATH Acquisition incorporates a data-independent acquisition strategy and has re-invigorated the proteomics community’s interest in comprehensive data by fragmenting every detectable peptide in the sample in order to acquire quantitative MS/MS data. This approach has been shown to increase the capacity of targeted proteomics experiments by over 30-fold and reduce study time by as much as 90 percent. Now, with the increased dynamic range of the TripleTOF 6600 System, researchers can more deeply interrogate complex samples. Combined with innovative variable window acquisition and the SWATH 2.0 processing software, a significant improvement in quantitative results has been realized.
Ruedi Aebersold, Ph.D., professor at the Institute of Molecular Biology at the ETH in Zurich, Switzerland, comments, "SWATH has already proven its enormous value as a critical discovery and large-scale quantification workflow. The combination of variable window SWATH acquisition with the increased dynamic range of the TripleTOF 6600 will give biological scientists a more precise and complete view of each sample, potentially leading to biological insights that have never been achieved before.”
Early experiments comparing TripleTOF 6600 System with SWATH 2.0 to other systems have demonstrated the quantification of up to 90 percent more peptides with CVs of less than 20 percent (a threshold often used to determine good limits of quantitation in LC/MS data). These advances in capacity and data completeness are expected to make integration with large-scale biology experiments, such as genomics and transcriptomics, much more accessible.
“To take advantage of the full potential of proteomics in translational research, we need to quantitate thousands of proteins in a single experiment with accuracy,” said Jennifer Van Eyk, Ph.D., Director of the Advanced Clinical Biosystems Institute at Cedars-Sinai Medical center and Director of basic science research in the Barbara Streisand Women’s Heart Center in the Cedars-Sinai Heart Institute and the Erika J. Glazer Chair in Women’s Heart Health. “The TripleTOF and SWATH system has enabled us to do this for the first time and contributed to accelerating my research objectives.”
About AB SCIEX
AB SCIEX helps to improve the world we live in by enabling scientists and laboratory analysts to push the limits in their field and address the complex analytical challenges they face. The company's global leadership and world-class service and support in the liquid chromatography-mass spectrometry industry have made it a trusted partner to thousands of the scientists and lab analysts worldwide who are focused on basic research, drug discovery and development, food and environmental testing, forensics and clinical research. With over 25 years of proven innovation, AB SCIEX excels by listening to and understanding the ever-evolving needs of its customers to develop reliable, sensitive and intuitive solutions that continue to redefine what is achievable in routine and complex analysis. For more information, please go to www.absciex.com.
Follow AB SCIEX on Twitter @ABSCIEX and on Facebook.
© 2014. AB SCIEX. AB Sciex Instruments Are For Research Use Only. Not for use in diagnostic procedures. The trademarks mentioned herein are the property of AB Sciex Pte. Ltd. or their respective owners. AB SCIEXTM is being used under license.
“We help people build clusters, in the classical sense of the cluster. We help people put a full stack on top of every single one of those machines. We do the full bare metal install," explained Greg Bruno, Vice President of Engineering and co-founder of StackIQ, in this SYS-CON.tv interview at 15th Cloud Expo, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
Dec. 18, 2014 02:30 PM EST Reads: 610
The cloud is becoming the de-facto way for enterprises to leverage common infrastructure while innovating and one of the biggest obstacles facing public cloud computing is security. In his session at 15th Cloud Expo, Jeff Aliber, a global marketing executive at Verizon, discussed how the best place for web security is in the cloud. Benefits include: Functions as the first layer of defense Easy operation –CNAME change Implement an integrated solution Best architecture for addressing network-l...
Dec. 18, 2014 02:00 PM EST Reads: 717
“DevOps is really about the business. The business is under pressure today, competitively in the marketplace to respond to the expectations of the customer. The business is driving IT and the problem is that IT isn't responding fast enough," explained Mark Levy, Senior Product Marketing Manager at Serena Software, in this SYS-CON.tv interview at DevOps Summit, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
Dec. 18, 2014 02:00 PM EST Reads: 987
DevOps Summit 2015 New York, co-located with the 16th International Cloud Expo - to be held June 9-11, 2015, at the Javits Center in New York City, NY - announces that it is now accepting Keynote Proposals. The widespread success of cloud computing is driving the DevOps revolution in enterprise IT. Now as never before, development teams must communicate and collaborate in a dynamic, 24/7/365 environment. There is no time to wait for long development cycles that produce software that is obsolete...
Dec. 18, 2014 01:45 PM EST Reads: 619
Mobile commerce traffic is surpassing desktop, yet less than 20% of sales in the U.S. are mobile commerce sales. In his session at 15th Cloud Expo, Dan Franklin, Segment Manager, Commerce, at Verizon Digital Media Services, defined mobile devices and discussed how next generation means simplification. It means taking your digital content and turning it into instantly gratifying experiences.
Dec. 18, 2014 12:00 PM EST Reads: 946
“In the past year we've seen a lot of stabilization of WebRTC. You can now use it in production with a far greater degree of certainty. A lot of the real developments in the past year have been in things like the data channel, which will enable a whole new type of application," explained Peter Dunkley, Technical Director at Acision, in this SYS-CON.tv interview at @ThingsExpo, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
Dec. 18, 2014 11:30 AM EST Reads: 760
SYS-CON Events announced today that Windstream, a leading provider of advanced network and cloud communications, has been named “Silver Sponsor” of SYS-CON's 16th International Cloud Expo®, which will take place on June 9–11, 2015, at the Javits Center in New York, NY. Windstream (Nasdaq: WIN), a FORTUNE 500 and S&P 500 company, is a leading provider of advanced network communications, including cloud computing and managed services, to businesses nationwide. The company also offers broadband, p...
Dec. 18, 2014 11:00 AM EST Reads: 2,078
The major cloud platforms defy a simple, side-by-side analysis. Each of the major IaaS public-cloud platforms offers their own unique strengths and functionality. Options for on-site private cloud are diverse as well, and must be designed and deployed while taking existing legacy architecture and infrastructure into account. Then the reality is that most enterprises are embarking on a hybrid cloud strategy and programs. In this Power Panel at 15th Cloud Expo (http://www.CloudComputingExpo.com...
Dec. 18, 2014 10:30 AM EST Reads: 2,213
Verizon Enterprise Solutions is simplifying the cloud-purchasing experience for its clients, with the launch of Verizon Cloud Marketplace, a key foundational component of the company's robust ecosystem of enterprise-class technologies. The online storefront will initially feature pre-built cloud-based services from AppDynamics, Hitachi Data Systems, Juniper Networks, PfSense and Tervela. Available globally to enterprises using Verizon Cloud, Verizon Cloud Marketplace provides a one-stop shop fo...
Dec. 18, 2014 10:30 AM EST Reads: 1,754
Leysin American School is an exclusive, private boarding school located in Leysin, Switzerland. Leysin selected an OpenStack-powered, private cloud as a service to manage multiple applications and provide development environments for students across the institution. Seeking to meet rigid data sovereignty and data integrity requirements while offering flexible, on-demand cloud resources to users, Leysin identified OpenStack as the clear choice to round out the school's cloud strategy. Additional...
Dec. 18, 2014 10:30 AM EST Reads: 1,815
The Internet of Things is not new. Historically, smart businesses have used its basic concept of leveraging data to drive better decision making and have capitalized on those insights to realize additional revenue opportunities. So, what has changed to make the Internet of Things one of the hottest topics in tech? In his session at @ThingsExpo, Chris Gray, Director, Embedded and Internet of Things, discussed the underlying factors that are driving the economics of intelligent systems. Discover ...
Dec. 18, 2014 10:15 AM EST Reads: 2,041
"Our premise is Docker is not enough. That's not a bad thing - we actually love Docker. At ActiveState all our products are based on open source technology and Docker is an up-and-coming piece of open source technology," explained Bart Copeland, President & CEO of ActiveState Software, in this SYS-CON.tv interview at DevOps Summit at Cloud Expo®, held Nov 4-6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
Dec. 18, 2014 10:00 AM EST Reads: 1,805
SYS-CON Media announced today that Aruna Ravichandran, VP of Marketing, Application Performance Management and DevOps at CA Technologies, has joined DevOps Journal’s authors. DevOps Journal is focused on this critical enterprise IT topic in the world of cloud computing. DevOps Journal brings valuable information to DevOps professionals who are transforming the way enterprise IT is done. Aruna's inaugural article "Four Essential Cultural Hacks for DevOps Newbies" discusses how to demonstrate the...
Dec. 18, 2014 10:00 AM EST Reads: 1,617
"BSQUARE is in the business of selling software solutions for smart connected devices. It's obvious that IoT has moved from being a technology to being a fundamental part of business, and in the last 18 months people have said let's figure out how to do it and let's put some focus on it, " explained Dave Wagstaff, VP & Chief Architect, at BSQUARE Corporation, in this SYS-CON.tv interview at @ThingsExpo, held Nov 4-6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
Dec. 18, 2014 10:00 AM EST Reads: 1,733
The move in recent years to cloud computing services and architectures has added significant pace to the application development and deployment environment. When enterprise IT can spin up large computing instances in just minutes, developers can also design and deploy in small time frames that were unimaginable a few years ago. The consequent move toward lean, agile, and fast development leads to the need for the development and operations sides to work very closely together. Thus, DevOps become...
Dec. 18, 2014 10:00 AM EST Reads: 1,856