SYS-CON MEDIA Authors: Zakia Bouachraoui, Liz McMillan, Carmen Gonzalez, Roger Strukhoff, David Linthicum

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Novacea Announces Positive AQ4N Phase 1 Study in Lymphoma at ASH Annual Meeting

Data Supports Broader Clinical Program for AQ4N

SOUTH SAN FRANCISCO, CA -- (MARKET WIRE) -- 12/11/06 -- Novacea, Inc. (NASDAQ: NOVC) today announced that Phase 1 data of AQ4N (banoxantrone), an investigational anti-cancer prodrug, demonstrated that AQ4N was active and well tolerated when administered to patients with non-Hodgkin's, chronic lymphocytic and Hodgkin's lymphomas. Results from the Phase 1, open-label, dose-escalation study at Weill Medical College of Cornell University, Washington University School of Medicine, and The Johns Hopkins University, were presented by investigators at the American Society of Hematology (ASH) 48th Annual Meeting on Sunday, December 10, 2007.

"AQ4N is a proprietary anti-cancer prodrug with a novel mechanism of action. We are pleased and encouraged by the results of this study as it demonstrates that AQ4N is well tolerated in patients with lymphoid malignancies, including those patients with compromised bone marrow function. Notably, AQ4N did demonstrate activity in lymphoid malignancies," said John Curd, M.D., president and chief medical officer at Novacea. "Based on the data from this study and observations from previous Phase 1 trials in patients with advanced cancers of several solid tumor types, we look forward to expanding the clinical development of AQ4N in lymphoid malignancies as well as solid tumors in 2007," added Dr. Curd.

The objectives of the Phase 1 study were to determine the maximum tolerated dose (MTD), dose limiting toxicity (DLT), and safety of AQ4N when administered on day 1 of a 21-day cycle in 11 previously treated patients with lymphomas. This study demonstrated that doses of AQ4N up to and including 1200 mg/m2 were well tolerated. No DLT was observed in this study and no clinical MTD could be identified. One patient in this study with follicular lymphoma who received 8 cycles of AQ4N at 1200 mg/m2 showed a partial response of six-months in duration. Seven serious adverse events were observed in six patients, however, none were deemed AQ4N-related by the investigators. Importantly, myelosuppression was not observed in the study patients even though half of the patients began the study with compromised bone marrow function due to their advanced disease or previous chemotherapy treatments.

An analysis of the pharmacokinetics demonstrated that AQ4N exhibits dose-dependent linear pharmacokinetics. As expected, the inactive prodrug, AQ4N, was not significantly activated in the circulation as very little of the activated drug, AQ4, or the intermediate metabolite, AQ4M, was detected in patients' serum. These observations in lymphoma patients are consistent with previous studies in patients with advanced solid tumors where tumor selective activation of AQ4N was demonstrated and suggest that AQ4N is also selectively activated within lymphoid tumors.

AQ4N is an investigational prodrug designed to address the challenges of treating certain cancers with significant hypoxic (oxygen starved) regions. AQ4N is selectively bioreduced by cytochrome P45 to AQ4, a potent DNA intercalator and topoisomerase II inhibitor. Preclinical studies demonstrate that AQ4N selectively targets lymphoblastoid cell lines as well as the hypoxic portions of solid tumors.

Novacea acquired North American rights to AQ4N from KuDOS Pharmaceuticals Limited (KuDOS). AQ4N was originally discovered by Professor Laurence Patterson, Ph.D., currently director of the Institute of Cancer Research at the University of Bradford in England, working in collaboration with the intellectual property and technology commercialization company, BTG. KuDOS acquired a worldwide license for AQ4N from BTG in March 2001.

About Novacea

Novacea, Inc. is a biopharmaceutical company focused on in-licensing, developing and commercializing novel cancer therapies. Novacea has two product candidates in clinical trials, including Asentar(TM), which currently is in a Phase 3 clinical trial for androgen-independent prostate cancer, or AIPC. Novacea's second product candidate, AQ4N, is a hypoxia-activated prodrug that is currently in a Phase 1b/2a clinical trial in glioblastoma multiforme. More information on any of Novacea's trials can be found at www.ClinicalTrials.gov.

Note: Except for the historical information contained herein, the matters set forth in this press release, including statements as to financial guidance, development, clinical studies, regulatory review and approval, and commercialization of products, are forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements speak only as of the date the statements are made and are based on information available at the time those statements are made and/or management's good faith belief as of that time with respect to future events. You should not put undue reliance on any forward-looking statements. Important factors that could cause actual performance and results to differ materially from the forward-looking statements we make include: early stage of development; the focus, conduct, enrollment and timing of our clinical trials; regulatory review and approval of product candidates; commercialization of products; developments relating to our licensing and collaboration agreements; market acceptance of products; funding requirements; intellectual property protection for our product candidates; competing products and other risks detailed from time to time under the heading "Risk Factors" in our most recent Quarterly Report on Form 10-Q, as may be updated from time to time by our future filings under the Securities Exchange Act. If one or more of these risks or uncertainties materialize, or if any underlying assumptions prove incorrect, our actual performance or results may vary materially from any future performance or results expressed or implied by these forward-looking statements. We assume no obligation to update forward-looking statements to reflect actual performance or results, changes in assumptions or changes in other factors affecting forward-looking information, except to the extent required by applicable securities laws.

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