SYS-CON MEDIA Authors: Trevor Parsons, Sean Houghton, Glenn Rossman, Ignacio M. Llorente, Xenia von Wedel

News Feed Item

The Overtreatment Conundrum: Definiens Identifies Three Steps for Advancing Diagnostics to Reduce Unnecessary Cancer Treatment and Improve Patient Health

Definiens, the global leader in Tissue Phenomics™ for diagnostics development in oncology, today released tips for the development of diagnostics to help physicians make more informed decisions, reduce unnecessary treatment and improve overall patient health. As the global cost of cancer care continues to rise exponentially, tests based on data generated from the analysis of tissue samples can play a critical role in helping improve stratification to provide patients with effective personalized care.

The overtreatment of cancer represents a significant and complex issue from both a health economics and patient care perspective. Studies published in the New England Journal of Medicine report “the annual direct costs of cancer care are projected to rise from $104 billion in 2006 to over $173 billion in 2020.” The problem, however, is that the current clinical and pathological parameters for diagnosing many cancer-types fail to accurately segment individual patients into specific risk groups. Many patients with low to intermediate stage cancers often receive the same level of aggressive treatment administered to patients with advanced, late-stage cancers. The result? Much of the money is spent on treatments that are unnecessary; leaving many patients needlessly exposed to potentially harmful side effects and long-term health consequences.

“The pervasive problem of cancer overtreatment highlights the urgent need for tests that can improve stratification in order to accurately identify those patient groups that require aggressive treatment, while allowing clinicians to separate out low-risk patients that will benefit from active surveillance,” said Dr. Ralf Huss, Chief Medical Officer of Definiens. “Definiens Tissue Phenomics™ solutions provides researchers with the necessary tools to extract, analyze and correlate all relevant data from heterogeneous tissue samples in order to develop innovative diagnostic tests with the capacity to inform better treatment decisions, lower healthcare costs and meet the needs of individual patients.”

Definiens’ three steps for the development of diagnostics that can reduce unnecessary cancer treatment and improve patient health include:

1. Recognize the Importance of Analyzing Intact Tissue

Over the past decade, advancements in next generation sequencing have proven essential for the molecular subgrouping of patients on the basis of genomic data. However, because there is only partial correlation between gene mutations, gene expression and actual tumor behavior, genomic information alone only provides a first-stage projection of cancer development. Conversely, focusing on the data that resides in intact tissue samples, including the number, shape, size and morphology of different structures and cells and proteins active in and around the tumor, will allow researchers to derive a more precise understanding of tumor biology and identify more effective biomarkers as result.

2. Focus on the Entire Tumor Microenvironment

Among researchers, a focus on genomics has often led to a preoccupation with the tumor itself. However, recent advances in immunotherapy indicate that the development of effective tests that have the ability to determine the likelihood of tumor recurrence and long-term treatment success require image analysis of the entire tumor microenvironment. This includes an understanding of the ways in which cancer cells change and grow in relation to surrounding cellular tissue. Looking at the larger context in which the tumor exists can better inform treatment decisions by providing invaluable insights regarding the probability of cancer progression.

3. Take a Big Data Approach to Tissue Analysis

To be sure, the data that resides in tissue samples is both vast and heterogeneous. Consequently, it is also far too complex and voluminous for human analysis alone. Automated image analysis and data mining that can fully quantify and extract all of the data that resides in tissue samples are critical for the development of tests with real prognostic value. In this regard, a big data approach that allows researchers to correlate information from multiple sources, including complex tissue signatures and genomic profiles, can provide the comprehensive picture needed for superior personalized and targeted treatment decisions.

About Definiens

Definiens is the global leader in Tissue Phenomics™ for discovery and diagnostics development in oncology and provides image analysis solutions for life sciences. Definiens' technology provides detailed tissue biomarker readouts from slide images and enables the correlation of this information with other key clinical or genomic information, an approach known as Tissue Phenomics™. Definiens helps pharmaceutical and biotechnology companies, research institutions, clinical service organizations and pathologists to generate new knowledge and support better decisions in research, diagnostics and therapy.

Definiens’ vision is to open new fields of research, to contribute to development of personalized medicine, and to significantly improve the quality of patients' lives. Definiens is headquartered in Munich, Germany and has its North American headquarters in Carlsbad, CA. Further information is available at www.definiens.com.

More Stories By Business Wire

Copyright © 2009 Business Wire. All rights reserved. Republication or redistribution of Business Wire content is expressly prohibited without the prior written consent of Business Wire. Business Wire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
In high-production environments where release cycles are measured in hours or minutes — not days or weeks — there's little room for mistakes and no room for confusion. Everyone has to understand what's happening, in real time, and have the means to do whatever is necessary to keep applications up and running optimally. DevOps is a high-stakes world, but done well, it delivers the agility and performance to significantly impact business competitiveness.
"Our premise is Docker is not enough. That's not a bad thing - we actually love Docker. At ActiveState all our products are based on open source technology and Docker is an up-and-coming piece of open source technology," explained Bart Copeland, President & CEO of ActiveState Software, in this SYS-CON.tv interview at DevOps Summit at Cloud Expo®, held Nov 4-6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
ScriptRock makes GuardRail, a DevOps-ready platform for configuration monitoring. Realizing we were spending way too much time digging up, cataloguing, and tracking machine configurations, we began writing our own scripts and tools to handle what is normally an enormous chore. Then we took the concept a step further, giving it a beautiful interface and making it simple enough for our bosses to understand. We named it GuardRail after its function - to allow businesses to move fast and stay sa...
The Internet of Things is not new. Historically, smart businesses have used its basic concept of leveraging data to drive better decision making and have capitalized on those insights to realize additional revenue opportunities. So, what has changed to make the Internet of Things one of the hottest topics in tech? In his session at @ThingsExpo, Chris Gray, Director, Embedded and Internet of Things, discussed the underlying factors that are driving the economics of intelligent systems. Discover ...
"BSQUARE is in the business of selling software solutions for smart connected devices. It's obvious that IoT has moved from being a technology to being a fundamental part of business, and in the last 18 months people have said let's figure out how to do it and let's put some focus on it, " explained Dave Wagstaff, VP & Chief Architect, at BSQUARE Corporation, in this SYS-CON.tv interview at @ThingsExpo, held Nov 4-6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
SYS-CON Media announced today that Sematext launched a popular blog feed on DevOps Journal with over 6,000 story reads over the weekend. DevOps Journal is focused on this critical enterprise IT topic in the world of cloud computing. DevOps Journal brings valuable information to DevOps professionals who are transforming the way enterprise IT is done. Sematext is a globally distributed organization that builds innovative Cloud and On Premises solutions for performance monitoring, alerting an...
The major cloud platforms defy a simple, side-by-side analysis. Each of the major IaaS public-cloud platforms offers their own unique strengths and functionality. Options for on-site private cloud are diverse as well, and must be designed and deployed while taking existing legacy architecture and infrastructure into account. Then the reality is that most enterprises are embarking on a hybrid cloud strategy and programs. In this Power Panel at 15th Cloud Expo (http://www.CloudComputingExpo.com...
Verizon Enterprise Solutions is simplifying the cloud-purchasing experience for its clients, with the launch of Verizon Cloud Marketplace, a key foundational component of the company's robust ecosystem of enterprise-class technologies. The online storefront will initially feature pre-built cloud-based services from AppDynamics, Hitachi Data Systems, Juniper Networks, PfSense and Tervela. Available globally to enterprises using Verizon Cloud, Verizon Cloud Marketplace provides a one-stop shop fo...
Leysin American School is an exclusive, private boarding school located in Leysin, Switzerland. Leysin selected an OpenStack-powered, private cloud as a service to manage multiple applications and provide development environments for students across the institution. Seeking to meet rigid data sovereignty and data integrity requirements while offering flexible, on-demand cloud resources to users, Leysin identified OpenStack as the clear choice to round out the school's cloud strategy. Additional...
SYS-CON Events announced today that IDenticard will exhibit at SYS-CON's 16th International Cloud Expo®, which will take place on June 9-11, 2015, at the Javits Center in New York City, NY. IDenticard™ is the security division of Brady Corp (NYSE: BRC), a $1.5 billion manufacturer of identification products. We have small-company values with the strength and stability of a major corporation. IDenticard offers local sales, support and service to our customers across the United States and Canada...
SYS-CON Media announced today that Aruna Ravichandran, VP of Marketing, Application Performance Management and DevOps at CA Technologies, has joined DevOps Journal’s authors. DevOps Journal is focused on this critical enterprise IT topic in the world of cloud computing. DevOps Journal brings valuable information to DevOps professionals who are transforming the way enterprise IT is done. Aruna's inaugural article "Four Essential Cultural Hacks for DevOps Newbies" discusses how to demonstrate the...
The move in recent years to cloud computing services and architectures has added significant pace to the application development and deployment environment. When enterprise IT can spin up large computing instances in just minutes, developers can also design and deploy in small time frames that were unimaginable a few years ago. The consequent move toward lean, agile, and fast development leads to the need for the development and operations sides to work very closely together. Thus, DevOps become...
SYS-CON Events announced today that Windstream, a leading provider of advanced network and cloud communications, has been named “Silver Sponsor” of SYS-CON's 16th International Cloud Expo®, which will take place on June 9–11, 2015, at the Javits Center in New York, NY. Windstream (Nasdaq: WIN), a FORTUNE 500 and S&P 500 company, is a leading provider of advanced network communications, including cloud computing and managed services, to businesses nationwide. The company also offers broadband, p...
SYS-CON Events announced today that AIC, a leading provider of OEM/ODM server and storage solutions, will exhibit at SYS-CON's 16th International Cloud Expo®, which will take place on June 9-11, 2015, at the Javits Center in New York City, NY. AIC is a leading provider of both standard OTS, off-the-shelf, and OEM/ODM server and storage solutions. With expert in-house design capabilities, validation, manufacturing and production, AIC's broad selection of products are highly flexible and are conf...

ARMONK, N.Y., Nov. 20, 2014 /PRNewswire/ --  IBM (NYSE: IBM) today announced that it is bringing a greater level of control, security and flexibility to cloud-based application development and delivery with a single-tenant version of Bluemix, IBM's