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SYS-CON MEDIA Authors: Pat Romanski, William Schmarzo, Elizabeth White, Carmen Gonzalez, JP Morgenthal

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Targazyme, Inc. Awarded SBIR Grant From National Eye Institute

SAN ANTONIO, TX--(Marketwired - July 31, 2014) - Targazyme, Inc. (formerly America Stem Cell, Inc.) a clinical-stage biopharmaceutical company developing enzyme technologies and products to improve efficacy outcomes for cancer immunotherapy and cell therapy, announced today the receipt of an SBIR award to fund its program for a novel cell-based restorative approach to treat diabetes-related retinopathy. This SBIR award is from the National Eye Institute and Targazyme will be collaborating with Dr. Maria Grant from the Department of Ophthalmology at Indiana University School of Medicine to conduct the research.

Retinal vascular diseases remain a common cause of vision loss and blindness, with diabetes as the most common condition leading to retinopathy in adults in Western society. This scientific award to Targazyme will be used to explore the effect of applying Targazyme's product, TZ101, to patient-derived endothelial progenitor cells to enhance migration of these cells to damaged retinal tissue. Now moving into later stage clinical trials, TZ101 is shown to be safe in humans and to improve efficacy outcomes for cancer patients undergoing hematopoietic stem cell transplantation at MD Anderson Cancer Center.

The National Eye Institute supports research with respect to blinding eye diseases, visual disorders, mechanisms of normal visual function, preservation of sight, and the special health problems and requirements of individuals with impaired vision. These grants cover a range of product development sectors including therapeutics, devices and drug development.

"Targazyme's innovative technology, validated by strong preliminary preclinical studies, may allow for the first time, patients to use their own cells to effectively treat diabetic retinopathy," said Dr. Maria Grant, Professor of Ophthalmology at Indiana University School of Medicine.

"We are pleased to receive this grant from the National Eye Institute. These funds will accelerate Targazyme's efforts to expand into additional indications such as treatment of diabetic complications where there are compelling unmet medical needs," said Lynnet Koh, Chairman and Chief Executive Officer of Targazyme. "The support from the National Eye Institute provides additional validation of our development program and of TZ101's potential to meaningfully improve the clinical outcomes of cell therapy and regenerative medicine."

About Targazyme, Inc.
Targazyme, Inc. is a privately-held biotechnology company based in San Antonio, TX with additional offices in San Diego, CA and Basel, Switzerland. Its key technology platforms (TZ101 and TZ102) are designed to improve the homing and engraftment of a wide variety of therapeutic cells to target tissues. Applications in development include hematopoietic stem cell transplants, immunotherapies for solid tumors, cell therapies to ameliorate graft-versus-host and autoimmune diseases, and cell therapies for ischemic diseases such as myocardial infarction and stroke. Targazyme has partnerships and collaborations with Kyowa Hakko Kirin and Florida Biologix, as well as various medical research institutions including The University of Texas MD Anderson Cancer Center, Oklahoma Medical Research Foundation, Texas Transplant Institute, Case Western/University Hospitals, Scripps Hospitals, Fred Hutchinson Cancer Research Center, University of California San Diego, Sanford-Burnham Medical Research Institute and Indiana University. Learn more at http://www.targazyme.com.

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