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From the Wires
Axcan Pharma Continues Solid Growth in Fiscal 2007, With Record Revenue of $85.3 Million in the Second Quarter
PYLERA Launched in the US

By: Marketwire .
May. 10, 2007 09:00 PM

MONT-SAINT-HILAIRE, QUEBEC -- (MARKET WIRE) -- 05/10/07 -- Axcan Pharma Inc. (TSX: AXP) (NASDAQ: AXCA) -


- Revenue of $85.3 Million, a 17.2% Increase Compared to the Second
  Quarter of Fiscal 2006

- Diluted Income Per Share of $0.34, a 100.0 % Increase Compared to the
  Second Quarter of Fiscal 2006

- Revenue Guidance for Fiscal 2007 Increased to $312-$320 Million

- PYLERA Launched in the United States

- Regulatory Filing for ULTRASE to be Initiated by the End of the First
  Half of Calendar 2007, With a Zero-Overfill Formulation

Axcan Pharma Inc. today reported financial results for the second quarter of fiscal 2007, ended March 31, 2007 (all amounts are stated in U.S. dollars). Highlights for the quarter include:

- Revenue of $85.3 million, an increase of 17.2% compared to the second quarter of fiscal 2006

- Diluted income per share for the second quarter of 2007 amounted to $0.34, compared to diluted income per share of $0.17 a year earlier, a 100.0 % increase

- Revenue guidance for fiscal 2007 increased to $312-$320 million

- Launch of PYLERA in the United States

- Zero-overfill formulation of ULTRASE, which translates into a highly stable formulation with batch-to-batch consistency, to be filed with the FDA by the end of the first half of calendar 2007

"Axcan's financial performance in the second quarter of fiscal 2007 was again outstanding. We have started the fiscal year with very solid financial results, delivering better-than-expected revenue growth for the first two quarters. As we are confident we can maintain this positive momentum throughout the year, we are raising our revenue guidance for 2007," stated Frank Verwiel, M.D., President and Chief Executive Officer of Axcan. "We also added momentum to our product pipeline by successfully launching PYLERA in the United States and finalizing the development of ULTRASE, with a zero-overfill formulation, which translates into a highly stable formulation with batch-to-batch consistency. This formulation should allow us to remain a leader in the pancreatic enzyme market once we obtain approval," he added.

Total revenue for the three-month period ended March 31, 2007, was $85.3 million, compared with $72.8 million for the second quarter of fiscal 2006, an increase of 17.2%.

Based on available information, the Company estimates that wholesaler inventory levels were approximately four to six weeks for the second quarter of fiscal 2007, which negatively impacted revenue by approximately $4.0 million. However, based on its ongoing discussions with different wholesalers, the Company expects average wholesaler inventory levels to be approximately six weeks for fiscal 2007.

Net income for the second quarter of fiscal 2007 was $17.8 million, a 114.5% increase compared with net income of $8.3 million for the corresponding period in fiscal 2006. Diluted income per share for the second quarter of 2007 amounted to $0.34, compared to diluted income per share of $0.17 a year earlier, a 100.0 % increase.

PRODUCT DEVELOPMENT PIPELINE UPDATE

An update on Axcan's major projects follows:

PYLERA

Axcan launched PYLERA at the beginning of May 2007 in the United States. PYLERA is an innovative 3-in-1 capsule triple therapy for the eradication of Helicobacter pylori, a bacterium recognized as being the main cause of gastric and duodenal ulcers. Each PYLERA capsule contains biskalcitrate potassium (140 mg), metronidazole (125 mg) and tetracycline hydrochloride (125 mg). The U.S. patent on the PYLERA capsule technology extends through December 2018.

ULTRASE-VIOKASE

In April 2004, the U.S. Food and Drug Administration ("FDA") formally notified manufacturers of pancreatic insufficiency products that these drugs, which include ULTRASE and VIOKASE, must receive approval before April 2008 in order to remain on the market. The FDA published final guidelines aimed at assisting manufacturers of exocrine pancreatic insufficiency drug products in preparing and submitting New Drug Applications ("Guidance for Industry - Exocrine Pancreatic Insufficiency Drug Products - Submitting NDAs"; April 2006).

Axcan is pleased to report that following the completion of the majority of its Chemistry, Manufacturing and Controls work, the Company is able to announce that the ULTRASE formulation to be submitted for approval will be a zero-overfill, highly-stable, pancreatic enzyme replacement therapy used to treat exocrine pancreatic insufficiency as associated with, but not limited to, cystic fibrosis. This formulation has been designed to meet FDA guidelines for pancreatic enzyme replacement products.

Axcan is currently progressing toward the completion of the New Drug Application ("NDA") for ULTRASE and is planning to initiate regulatory filings aimed at obtaining the approval of an NDA by the end of the first half of calendar 2007. The Company reiterates that it is confident it will meet the deadline for NDA approval by April 2008.

Axcan is also progressing toward the completion of the NDA for VIOKASE, the only branded uncoated pancreatic enzyme formulation available in the United States. The Company is currently implementing a filing strategy to comply with FDA guidelines and timelines.

AGI-010

In September 2006, Axcan signed an exclusive license and co-development agreement with AGI Therapeutics, plc ("AGI") for AGI-010. AGI-010 is a delayed/controlled release formulation of the Proton Pump Inhibitor ("PPI") drug omeprazole and is being developed for the treatment of gastro-esophageal reflux disease ("GERD"), and in particular to address the control of nighttime gastric acidity, known as Nocturnal Acid Breakthrough ("NAB"). NAB remains a significant unmet medical need, and is estimated to occur in more than 50% of GERD patients on a PPI therapy. Development of the final formulation for this compound is in progress. Results of formulation optimization are expected to be available in the first half of calendar 2007, and, assuming the results are favourable, AGI and Axcan intend to initiate discussions with the FDA to evaluate the most appropriate development and filing strategy.

NCX-1000

Axcan and its partner, NicOx S.A., have been co-developing NCX-1000, a patented, nitric oxide-donating derivative of ursodiol, for the treatment of portal hypertension, a late-stage complication of some chronic, advanced liver diseases. A preliminary analysis of 11 patients in a "proof-of-concept", phase IIa randomized, double-blind, dose-escalating study, in which patients received either escalating doses of NCX-1000 or a placebo, confirmed the safety profile of NCX-1000 but did not demonstrate the efficacy required to support the continuation of this clinical trial. As a consequence, Axcan and NicOx have agreed not to further pursue the development of NCX-1000 and to terminate the clinical trial. The two companies will now proceed with full data analysis and results will be disclosed at a later date. Axcan and NicOx are actively evaluating opportunities for further collaborative development projects involving NicOx's technology, and Axcan is currently evaluating another NicOx molecule to be developed in the field of gastroenterology.

URSODIOL DISULFATE

Axcan is developing ursodiol disulfate in the prevention of the recurrence of colorectal adenomateous polyps. A single, ascending-dose Phase I clinical study was completed in early 2006, as well as a multiple, ascending-dose Phase I study completed in September 2006, to evaluate the safety, tolerability and preliminary pharmacokinetics of ursodiol disulfate. Both studies confirmed the safety and tolerability of this compound. Results of the pharmacokinetics part of the studies are currently being analyzed.

NMK 150

Axcan is developing NMK 150, a new high protease pancrelipase preparation developed for the relief of pain in small duct chronic pancreatitis, which represents an unmet medical need. A dose-ranging, animal study assessing the toxicity of NMK 150, which paid special attention to duodenal irritation, was completed and confirmed the safety profile of this compound. A Phase I, ascending, multiple-dose clinical study was also completed and confirmed the safety and tolerability of this compound alone and in combination with a PPI. Results of the pharmacodynamics part of the studies are currently being analyzed.

GUIDANCE FOR 2007

Axcan forecasts its revenue for the fiscal year ending September 30, 2007, to be in the range of $312 to $320 million, which represents growth of approximately 7% to 10% relative to fiscal 2006. Following the first quarter of fiscal 2007, Axcan announced updated guidance to be in the range of $307 to $312 million for fiscal 2007. During the first two quarters, the Company realized stronger than expected revenue as the Company's products for which prescription data is available showed more positive overall prescription trends than anticipated, which should result in higher annual sales than initially budgeted. In addition, solid revenue in Europe and the continued delayed impact of generic ursodiol in Canada contributed to the increase in revenue. However, the Company does not expect further growth in fiscal 2007 to match the quarter over quarter growth rates in the first two quarters. As generic ursodiol is now listed on all the Canadian provincial formularies, we are beginning to see a negative impact on sales of this product. Revised guidance includes the effects of generic erosion on the ursodiol franchise in Canada, as well as the ongoing effects of budgetary initiatives implemented by the French government during fiscal 2006 on the Company's products LACTEOL and TAGAMET.

Revenue forecasts are based upon a number of variables and assumptions, including prescription and business trends as well as the impact on patient assistance programs in response to the new Medicare Part D program. Furthermore, the Company's revenue guidance does not include the impact of future business development activities, including any future acquisitions, in-licensing or distribution agreements.

Axcan's operating expenses are largely project-based and will impact future quarters based on certain planned events. These operating expenses include the launch of new products, the impact of an ongoing concerted effort in the area of business development, and the further advancing of the Company's research and development pipeline.

At the beginning of fiscal 2007, the Company anticipated research and development expenses to fall within the range of approximately 9% to 12% of total revenue as, in addition to advancing its current portfolio, the Company plans to continue to implement lifecycle management programs, in order to extend and defend its base portfolio. This projection also included costs associated with the filing of the New Drug Applications (NDAs) for the Company's two pancreatic enzyme products. The Company currently believes these expenses will be at the lower end of the given range.

The Company also expected 2007 selling and administrative expenses to be approximately 32% to 34% of total revenue, including costs associated with launch of PYLERA, which occurred on May 7, 2007, and ongoing costs associated with Sarbanes-Oxley compliance. The Company also believes expenses will fall at the lower end of the range for this expense category.

Although the Company believes that the expectations reflected in this guidance are reasonable, these statements consist of projections, based upon a number of variables and assumptions, all of which are subject to uncertainties and risks. Material assumptions include, but are not limited to: wholesaler inventory levels in fiscal 2007 being approximately six weeks; the absence of any changes to U.S. GAAP applicable to revenue recognition; foreign currency rates remaining stable throughout the year; the absence of any material change in reimbursement amounts and policies related to the Company's products in all markets; the absence of any material change in the regulatory status of the Company's current products and the absence of additional competitive products and generic entries.

Additional information on assumptions and risk factors that could cause actual results to differ may be found in the Management's Discussion and Analysis ("MD&A"), accessible on the Company's website (www.axcan.com), as well as in the Company's filings with the Securities and Exchange Commission and the Canadian securities regulators. The Company intends to update or revise guidance annually or as otherwise dictated by a change in a material assumption or factor underlying its guidance.

INTERIM FINANCIAL REPORT

This press release contains the condensed financial statements derived from the unaudited consolidated interim financial statements for the three-month period ended March 31, 2007. For a copy of our full financial results for the second quarter, including the Management's Discussion and Analysis and Interim Financial Statements, please visit our website at www.axcan.com.

CONFERENCE CALL

Axcan will host a conference call at 8:30 A.M. ET, on May 11, 2007. Interested parties may also access the conference call by way of a webcast at www.axcan.com. The webcast will be archived for 90 days. The telephone numbers to access the conference call are (800) 595-8550 (Canada and United States) or (416) 644-3427 (international). A replay of the call will be available until May 18, 2007. The telephone numbers to access the replay of the call are (877) 289-8525 or (416) 640-1917, passcode 21228653#.

ABOUT AXCAN PHARMA

Axcan is a leading multinational specialty pharmaceutical company focused on gastroenterology. The company develops and markets a broad line of prescription products to treat a range of gastrointestinal diseases and disorders such as inflammatory bowel disease, irritable bowel syndrome, cholestatic liver diseases and complications related to pancreatic insufficiency. Axcan's products are marketed by its own specialized sales forces in North America and Europe. Its common shares are listed on the NASDAQ Global Market under the symbol "AXCA" and on the Toronto Stock Exchange under the symbol "AXP".

Caution regarding guidance and Forward-Looking Information and "Safe Harbor" statement under the Private Securities Litigation Reform Act of 1995

This release contains forward-looking statements, which reflect the Company's current expectations regarding future events. To the extent any statements made in this release contain information that is not historical, these statements are essentially forward-looking, including, without limitation, the Company's guidance for fiscal 2007 in respect of revenues, research and development expenses as well as selling and administrative expenses and are generally identified by words such as "anticipate," "expect," "estimate," "intend," "project," "plan" and "believe." Forward-looking statements are subject to risks and uncertainties and undue reliance should not be placed on these statements. Certain material assumptions are applied in making forward-looking statements, and actual results may differ materially from those expressed or implied in such statements. Important factors that could cause actual results to differ materially from these expectations are outlined in the body of this news release, and also include the difficulty of predicting FDA and other regulatory approvals, acceptance and demand for new pharmaceutical products, the impact of competitive products and pricing, new product development and launch, reliance on key strategic alliances, availability of raw materials, the regulatory environment, fluctuations in operating results, the protection of our intellectual property and other risks detailed from time to time in the Company's filings with the Securities and Exchange Commission and the Canadian securities regulators.

The Company cautions that the foregoing list of factors that may affect future results is not exhaustive. Axcan undertakes no obligation to update or revise any forward-looking statement, unless obligated to do so pursuant to applicable securities laws and regulations.

The names CANASA, CARAFATE, DELURSAN, LACTEOL, PANZYTRAT, PYLERA, SALOFALK, ULTRASE, URSO, URSO DS, URSO 250, URSO FORTE and VIOKASE appearing in this press release are trademarks of Axcan Pharma Inc. and its subsidiaries.


                   CONSOLIDATED BALANCE SHEETS
---------------------------------------------------------------------
---------------------------------------------------------------------

      (in thousands of U.S. dollars, except share related data)

                                             March 31, September 30,
                                                 2007          2006
---------------------------------------------------------------------
                                           (unaudited)
                                                    $             $

Assets

Current assets
  Cash and cash equivalents                   206,481        55,830
  Short-term investments, available for sale   18,349       117,151
  Accounts receivable, net                     46,223        30,939
  Income taxes receivable                       6,673         8,987
  Inventories                                  29,696        37,349
  Prepaid expenses and deposits                 3,388         3,699
  Deferred income taxes                        11,840         8,423
---------------------------------------------------------------------
Total current assets                          322,650       262,378

Property, plant and equipment, net             29,605        28,817
Intangible assets, net                        370,474       375,680
Goodwill, net                                  27,467        27,467
Deferred debt issue expenses, net                 925         1,475
Deferred income taxes                           3,994             -
---------------------------------------------------------------------
Total assets                                  755,115       695,817
---------------------------------------------------------------------
---------------------------------------------------------------------

Liabilities

Current liabilities
  Accounts payable and accrued liabilities     64,920        60,733
  Income taxes payable                          9,477         2,099
  Instalments on long-term debt                   588           681
  Deferred income taxes                         1,459         1,104
---------------------------------------------------------------------
Total current liabilities                      76,444        64,617

Long-term debt                                125,349       125,565
Deferred income taxes                          39,606        38,211
---------------------------------------------------------------------
Total liabilities                             241,399       228,393
---------------------------------------------------------------------

Shareholders' Equity

Capital stock
  Preferred shares, without
   par value; unlimited shares
   authorized: no shares issued                     -             -
  Series A preferred shares,
   without par value; shares authorized:
   14,175,000; no shares issued                     -             -
  Series B preferred shares,
   without par value; shares authorized:
   12,000,000; no shares issued                     -             -
  Common shares, without par value;
   unlimited shares authorized:
   46,015,945 issued and outstanding
   as at March 31, 2007 and 45,800,581
   as at September 30, 2006                   265,101       262,786
Retained earnings                             213,225       177,906
Additional paid-in capital                      7,300         4,967
Accumulated other comprehensive income         28,090        21,765
---------------------------------------------------------------------

Total shareholders' equity                    513,716       467,424
---------------------------------------------------------------------
Total liabilities and shareholders' equity    755,115       695,817
---------------------------------------------------------------------
---------------------------------------------------------------------

These condensed financial statements should be read in conjunction
with the annual Consolidated Financial Statements.



                      CONSOLIDATED OPERATIONS
---------------------------------------------------------------------
---------------------------------------------------------------------

      (in thousands of U.S. dollars, except share related data)
                             (unaudited)

                        For the     For the     For the     For the
                          three-      three-        six-        six-
                          month       month       month       month
                         period      period      period      period
                          ended       ended       ended       ended
                       March 31,   March 31,   March 31,   March 31,
                           2007        2006        2007        2006
---------------------------------------------------------------------
                              $           $           $           $

Revenue                  85,320      72,770     164,139     143,409
---------------------------------------------------------------------

Cost of goods sold (a)   21,403      18,466      40,617      36,695
Selling and
 administrative
 expenses (a)            24,890      22,888      47,035      46,530
Research and
 development
 expenses (a)             7,638       7,288      13,849      16,182
Depreciation
 and amortization         5,504       5,649      10,906      11,283
Partial write-down
 of intangible assets         -       5,800           -       5,800
---------------------------------------------------------------------
                         59,435      60,091     112,407     116,490
---------------------------------------------------------------------

Operating income         25,885      12,679      51,732      26,919
---------------------------------------------------------------------

Financial expenses        1,731       1,737       3,514       3,495
Interest income          (2,576)       (971)     (4,644)     (1,757)
Loss (Gain) on
 foreign currency           392        (335)        282        (545)
---------------------------------------------------------------------
                           (453)        431        (848)      1,193
---------------------------------------------------------------------

Income before
 income taxes            26,338      12,248      52,580      25,726
Income taxes              8,520       3,926      17,261       8,159
---------------------------------------------------------------------
Net income               17,818       8,322      35,319      17,567
---------------------------------------------------------------------
---------------------------------------------------------------------

Income per
 common share
  Basic                    0.39        0.18        0.77        0.38
  Diluted                  0.34        0.17        0.68        0.36
---------------------------------------------------------------------
---------------------------------------------------------------------

Weighted average
 number of
 common shares
  Basic              45,972,131  45,712,790  45,909,282  45,711,291
  Diluted            55,438,687  55,215,847  55,318,694  55,140,379
---------------------------------------------------------------------
---------------------------------------------------------------------
(a) Exclusive of depreciation and amortization

These condensed financial statements should be read in conjunction
with the annual Consolidated Financial Statements.



                       KEY PRODUCT INFORMATION
---------------------------------------------------------------------
---------------------------------------------------------------------

---------------------------------------------------------------------
                        Q2 2007       Fiscal 2007     Prescriptions
                                          to date        Increase(1)
---------------------------------------------------------------------
                                                             Fiscal
                          Sales             Sales              2007
                 Sales Increase    Sales increase  Q2 2007  to date
                (US$ M)      (%)  (US$ M)      (%)      (%)      (%)
---------------------------------------------------------------------
NORTH AMERICA
---------------------------------------------------------------------
CANASA            14.7     48.0     27.2     24.0      4.0      4.0
---------------------------------------------------------------------
SALOFALK           4.1      0.6      9.6     15.1      7.9      8.1
---------------------------------------------------------------------
ULTRASE           12.4      4.6     22.4     18.3      9.0      4.6
---------------------------------------------------------------------
URSO 250/FORTE/DS 20.5     55.1     38.0     28.6      3.0(2)   3.0(2)
---------------------------------------------------------------------
CARAFATE          12.3      9.0     22.1     13.5      7.0      8.0
---------------------------------------------------------------------

---------------------------------------------------------------------
EUROPE
---------------------------------------------------------------------
LACTEOL            4.4    (23.2)     8.9    (17.6)     n/a      n/a
---------------------------------------------------------------------
PANZYTRAT          3.5     33.4      8.2     29.7      n/a      n/a
---------------------------------------------------------------------
DELURSAN           4.1     24.3      8.0     19.2      n/a      n/a
---------------------------------------------------------------------

(1) Compared with the same period a year earlier
(2) Based on IMS Prescription Data for products sold in the United
    States

PRODUCTS IN NORTH AMERICA

CANASA

CANASA sales for the quarter represented significant growth compared to the same period in 2006, as they increased 48% to $14.7 million. However, the dollar growth for this product does not reflect prescription growth, due to wholesaler ordering patterns experienced during both the second quarter of fiscal 2007 and the second quarter of fiscal 2006. Additionally, during the current quarter, the Company filled outstanding orders for CANASA 1000 mg, which were not shipped in the prior quarter due to lack of available finished goods inventory.

For the second quarter of fiscal 2007 and year to date, overall total CANASA prescriptions were up 4.0% compared to the comparable period in the prior year. However, in 2006, although CANASA 500 mg had already been taken off the market, this dosage form was still prescribed. An analysis of trends for CANASA 1000 mg alone shows that prescriptions were up 14% for the quarter and 21% for the year to date, compared to the same periods in the prior year. Considering that the prescription size in units dispensed of CANASA 1000 mg suppositories is similar to CANASA 500 mg, and taking into consideration the price differential between the 1000-mg and a 500-mg dosage forms, the Company can confirm it is experiencing much higher dollar growth than prescription growth. Furthermore, as Axcan transitions to new eligibility rules in its patient assistance programs, the Company is realizing revenues from prescriptions that were provided free of charge, or at a reduced cost in prior periods.

ULTRASE

For the second quarter of fiscal 2007, the increase in ULTRASE sales was slightly lower than prescription growth would indicate, but still represented a rate of 5.0% over sales for the same period in the prior year. Wholesaler buying patterns during the current and prior year account for the majority of the difference. Additionally, the price of ULTRASE was increased during the current quarter.

For the year to date, sales have increased significantly over the same period in the prior year due to a number of factors, such as prescription growth experienced due to promotional efforts of the Axcan U.S. sales force, and timing of wholesaler orders and shipments. Changes in the Axcan patient assistance programs have not had a significant impact on ULTRASE sales, as the Company continues to leverage its Care First and Comprehensive Care for CF Patients programs, for which no changes in the eligibility requirements have been made.

URSO 250/URSO FORTE

Ursodiol sales for the second quarter of fiscal 2007 were up significantly compared to the same period in 2006. However, the dollar growth does not reflect the prescription growth for this product, due to wholesaler ordering patterns experienced during the second quarter of fiscal 2007 and the comparable quarter for fiscal 2006.

For the second quarter of fiscal 2007, and year to date, overall ursodiol prescriptions were up 3.0%. URSO FORTE, a 500-mg dosage form of ursodiol launched in fiscal 2005, continues to contribute to overall prescription growth. Total prescription growth, when adjusted for dosage strength effect for the difference between 250-mg dosage, and 500-mg dosage prescriptions, showed an 8.0% increase during the second quarter, and the year. Furthermore, as Axcan transitions to new eligibility rules in its patient assistance programs, the Company is realizing revenues from prescriptions that were provided free of charge, or at a reduced cost in prior periods. The company has also seen an increase in the prescription size that contributed to dollar sales during the second quarter of fiscal 2007 and year to date.

CARAFATE

CARAFATE sales for the quarter and year increased in line with prescription growth. The Company continues to see growth in the CARAFATE franchise, mostly due to the promotional efforts in fiscal 2006 on CARAFATE oral suspension, which created prescription growth and increased the size of the prescription size dispensed.

PRODUCTS IN EUROPE

LACTEOL

For the second quarter, sales of LACTEOL in Europe and elsewhere in the world declined 23.2%, compared to the same period in fiscal 2006. In local currency, LACTEOL sales declined 30.4%, compared to the same period in fiscal 2006. Sales of this product are stable as compared to the first quarter of fiscal 2007. As previously disclosed, the Company believes that the sales impact caused by the delisting from French government formularies on March 1, 2006, has stabilized.

PANZYTRAT

For the second quarter, sales of PANZYTRAT expressed in U.S. dollars increased 33.4% compared to the same period in 2006.

In local currency, PANZYTRAT sales increased 21.4%, compared to the same period in fiscal 2006. This increase is, amongst other reasons, due to the signing of new distribution agreements for certain export markets.

DELURSAN

For the second quarter, sales of DELURSAN expressed in U.S. dollars increased 24.3% compared to the same period in 2006.

In local currency, DELURSAN sales increased 12.9%, compared to the same period in fiscal 2006. This is mainly due to the Company's decision to increase and refocus its commercial activities on gastroenterologists in France.

Contacts:
Axcan Pharma Inc.
Isabelle Adjahi
Senior Director, Investor Relations and Communications
450-467-2600 ext. 2000
www.axcan.com

Published May. 10, 2007— Reads 202
Copyright © 2007 SYS-CON Media, Inc. — All Rights Reserved.
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